Figure 4
From: Inhibition of matrix metalloproteinases reduces ischemia-reperfusion acute kidney injury
Immunohistochemical analysis of the expression of MMP-2 (a, d: × 400), TIMP-1 (b, e: × 400), and TIMP-2 (c, f: × 200), before ischemia control (a–c) and 6 h (d–f) after 60-min ischemia-reperfusion in MMP-2+/+ mice. At 6 h after ischemia-reperfusion when MMP-2 activities were highest, increased expression of MMP-2 (arrowhead) was evident in the interstitium around renal tubules. In contrast, tubular expression of TIMP-1 (arrow) and TIMP-2 (arrow) was decreased at 6 h after ischemia-reperfusion.
