Figure 6
From: Inhibition of matrix metalloproteinases reduces ischemia-reperfusion acute kidney injury
Electron microscopy showing peritubular capillary (PTC) injury at 6 h after 60-min ischemia-reperfusion in MMP-2+/+ mice (a, d: × 8,000; b, c: × 4,000). Disruption of the basement membrane (BM) (arrow in a) and destruction of PTCs were noted, together with interstitial edema and hemorrhage. Apoptotic endothelial cells (arrowhead in b) and swollen endothelial cells (* in c) were also seen in PTCs with intracapillary accumulation of platelets (arrowhead in d). Exudative red blood cells (arrow in b and d) were present aroud PTCs. Necrosis of tubular epithelial cells did not develop at 6 h after 60-min ischemia and reperfusion.
