Figure 9 | Laboratory Investigation

Figure 9

From: Novel guggulsterone derivative GG-52 inhibits NF-κB signaling in intestinal epithelial cells and attenuates acute murine colitis

Figure 9

Histologic score of colitis in mice treated with sulfasalazine, prednisolone, or the guggulsterone derivative GG-52. Mice were treated with vehicle (control), DSS alone, or DSS and sulfasalazine (200 mg/kg q.d.), DSS and prednisolone (1 mg/kg q.d.), or DSS and the guggulsterone derivative GG-52 (50 or 200 mg/kg q.d.), as described in the preventive model section of Materials and methods. The total histologic score was derived from the severity and extent of total inflammation and crypt damage (mean±s.d.). *P<0.05 compared with DSS alone.

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