Table 2 Effects of guggulsterone derivatives on clinical indices of colonic inflammation in the therapeutic murine model

From: Novel guggulsterone derivative GG-52 inhibits NF-κB signaling in intestinal epithelial cells and attenuates acute murine colitis

 

Body weight change (%)

Colon length to weight ratio (cm/g)

Disease activity index

Vehicle (control)

103.6±1.8

0.42±0.02

—

DSS

86.4±2.9

0.33±0.02

2.6±0.5

DSS+GG-52 (25 mg/kg)

83.9±3.9

0.34±0.04

1.7±0.8

DSS+GG-52 (100 mg/kg)

97.3±3.1*

0.38±0.01*

0.8 ±0.4*

  1. Data represent mean±s.d. (n=6). *P<0.05 compared with DSS alone.
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