Table 3 Effects of guggulsterone derivative GG-52 on clinical indices of colonic inflammation in the TNBS-induced colitis murine model

From: Novel guggulsterone derivative GG-52 inhibits NF-κB signaling in intestinal epithelial cells and attenuates acute murine colitis

 

Body weight change (%)

Colon length to weight ratio (cm/g)

Disease activity index

Vehicle (control)

100.8±1.6

0.49±0.03

—

TNBS

78.5±4.8

0.27±0.01

2.75±0.4

TNBS+GG-52 (200 mg/kg)

97.9±3.1*

0.31±0.03

0.90±0.72*

  1. Data represent mean±s.d. (n=5). *P<0.05 compared with TNBS alone.
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