Table 4 Clinical indices in mice with DDS-induced colitis treated with GG-52, sulfasalzine, or prednisolone

From: Novel guggulsterone derivative GG-52 inhibits NF-κB signaling in intestinal epithelial cells and attenuates acute murine colitis

 

Body weight change (%)

Colon length to weight ratio (cm/g)

Disease activity index

Vehicle (control)

103.6±1.77

0.42±0.02

—

DSS

82.1±2.59*

0.31±0.04*

3.0±0.0*

Sulfasalazine (200 mg/kg)

90.3±2.99†

0.40±0.08†

1.7±0.9†

Prednisolone (1 mg/kg)

89.6±3.40†

0.41±0.03†

1.8±1.3

GG-52 (200 mg/kg)

92.8±6.01†

0.42±0.03†

1.58±0.8†

  1. Data represent mean±s.d. (n=6). *P<0.05 compared with control; †P<0.05 compared with DSS alone.
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