Figure 1
From: Resveratrol enhances the sensitivity of cholangiocarcinoma to chemotherapeutic agents
Resveratrol renders cholangiocarcinoma cells, but not non-malignant cholangiocytes, more susceptible to chemotherapeutic agents in vitro. Cholangiocarcinoma cells (Mz-ChA-1, SG231, CCLP-1, and HuCCT-1) and non-malignant human cholangiocytes (H69) were treated with resveratrol (Resv; 20 μM) before the addition of 5-FU (30 μM; a), mitomycin C (Mito C; 5 μM; b), or gemcitabine (Gemc; 30 μM; c) for 48 h. Cell proliferation was assessed using an MTS cell proliferation assay. Data are expressed as fold change in proliferation (average±s.e.m., n=7). The * denotes significance (P<0.05) compared with basal, and the denotes significance (P<0.05) compared with the chemotherapy treatment alone.
