Figure 7 | Laboratory Investigation

Figure 7

From: Glutathione transferase kappa deficiency causes glomerular nephropathy without overt oxidative stress

Figure 7

Electron micrographs of kidney glomeruli. WT mice at 3 months (a) and 6 months (e) show normal GBM and foot process structure. Kidneys from Gstk1−/− mice at 3 months (b–d) of age show GBM changes including projections (filled arrows), splits (open arrows) and laminations (open arrow heads). Foot processes are still within normal ranges. Kidneys from Gstk1−/− mice at 6 months of age (f–i) show much more severe GBM changes, with no normal foot processes being evident (ie, complete effacement) in the areas included in images (g–i).

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