Figure 5 | Laboratory Investigation

Figure 5

From: Role of amino acid transporter LAT2 in the activation of mTORC1 pathway and the pathogenesis of crescentic glomerulonephritis

Figure 5

Activation of mammalian target of rapamycin complex 2 (mTORC2) in crescentic glomerulonephritis (CGN) glomeruli. (a) Western blot analysis shows a marked increase of phospho-AKT1 in CGN glomeruli (day 7) compared with control glomeruli. β-Actin shows internal control of each sample. (b) Immunohistochemistry reveals that the main lesion of increased phospho-AKT1 is in the proliferative mesangial cells (arrow), not in the crescent lesion (asterisk), in CGN glomerulus of day 2, day 5 and day 7.

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