Figure 2
From: Determining the contribution of NPM1 heterozygosity to NPM-ALK-induced lymphomagenesis
Histopathological presentation of tumors. (a) Hematoxylin and eosin-stained spleen and lymph node sections from CD2/NPM-ALK+NPM1+/+ and CD2/NPM-ALK+NPM1+/− mice presenting with tumor masses showing atypical lymphoid infiltrate disrupting the normal tissue architecture. (b) Immunohistochemical analysis of tumor sections to detect NPM-ALK expression. (c) Western blot analysis of NPM and actin expression levels in tumors isolated from CD2/NPM-ALK+NPM1+/+ and CD2/NPM-ALK+NPM1+/− mice compared with NPM+/− and NPM+/+ MEFs. The numbers refer to densitometric analysis of NPM expression levels in comparison to the respective actin control.
