Figure 1

(a) Serum levels of alanine aminotransferase (ALT) in C57BL/6 wild-type mice (WT; white bars) and CXCR3^−/− mice (black bars) at baseline as well as 24 and 72 h after injury (n=10–12/group). CXCR3^−/− animals have significantly higher ALT values compared with wild-type mice 24 h after CCl₄ injection. Results are shown as mean values±s.e.m. (^*P<0.05). Please note the logarithmic scale. (b) Representative liver histology (H&E staining; magnification × 200) of C57BL/6 wild-type mice (left) and CXCR3^−/− mice (right) at baseline as well as 24 and 72 h after liver injury. We observed no histological differences between wild-type and CXCR3^−/− mice at baseline. However, CXCR3^−/− mice show enlarged areas of liver damage (marked with black lines) 24 h after CCl₄-induced liver injury compared with corresponding wild-type mice. These enlarged areas of injury persist in CXCR3^−/− mice 72 h after CCl₄ administration, while wild-type mice have completely recovered at this time.