Table 1 Changes in serum biochemical parameters

	Adenine-administered period
Parameters	2 weeks (n=7)	4 weeks (n=7)	6 weeks (n=7)
Urea nitrogen (mg/dl)
Adenine	124.2±23.8^a	213.9±45.3^a	218.6±20.6^a
Control	23.6±3.6	26.8±5.1	27.2±5.4
Creatinine (mg/dl)
Adenine	1.3±0.3^a	2.0±0.3^a	2.1±0.3^a
Control	0.3±0.1	0.3±0.1	0.3±0.1
Calcium (mg/dl)
Adenine	11.3±0.8	9.1±1.6^a	9.2±1.6^b
Control	11.2±0.5	12.0±1.0	11.8±0.9
Inorganic phosphorus (mg/dl)
Adenine	14.8±2.6^b	20.1±6.7^a	16.1±2.6^b
Control	12.2±1.6	11.5±3.0	12.1±3.5
Intact PTH (pg/ml)
Adenine	868±641^b	5065±1233^a	5726±2352^a
Control	223±158	86±41	114±97
1,25(OH) ₂ D ₃ (pg/ml)
Adenine	41.1±30.8^b	3.9±1.4^a	8.7±4.7^a
Control	212.5±69.5	219.2±62.9	141.1±40.7
BALP (U/L)
Adenine	25.4±14.6	26.5±12.6^b	26.8±19.8
Control	22.3±5.8	16.7±7.5	21.4±5.9
TRACP-5b (mU/dl)
Adenine	1293±881^b	177±189^a	106±83^a
Control	2364±881	2438±881	2424±868

Abbreviations: BALP, serum bone alkaline phosphatase; TRACP-5b, serum tartrate-resistant acid phosphatase 5b derived from osteoclasts.
Data are shown as means±s.d. Significant differences were identified using the Mann–Whitney’s U-test.
^aP<0.01 vs control.
^bP<0.05.

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