Figure 3
Effect of 5-lipoxygenase (5-LO) inhibition by MK-886 on portal perfusion pressure and liver injury. Data are expressed as the mean±s.d. (a) The inhibition of 5-LO activation by the infusion of MK-886 (3 μM, n=6) from 20 to 50 min did not alter portal perfusion pressure in BDL animals. (b) Accordingly, LDH efflux as a sign of cell damage was not influenced by MK-886 treatment (3 μM, n=6) when infused from 20 to 50 min. (c) H&E staining showed no changes concerning liver injury following MK-886 treatment from 20 to 50 min compared with control animals. (d) Elastica van Gieson staining to estimate bile duct proliferation showed no influence on bile duct proliferates in MK-886-treated animals compared with untreated controls.
