Table 1 Intraperitoneal doses of L-arginine-HCl used to induce acute pancreatitis in mice
Dose (g/kg) | Time of killing (h) | Pancreatic damage as judged by histology | Other organ damage | Reference |
|---|---|---|---|---|
2 × 4a | 24, 48, 72, 96, 120 | Approx. 25–35% necrosis at 72–120 h | Lung | 13, 14 |
2 × 4.7 | 48, 72 | 48 h: approx. 6/12; 72 h: approx. 4/12; total histological score (based on edema: 0–3, inflammation: 0–3, acinar cell necrosis: 0–3, hemorrhage: 0–3) | No data | 18 |
2 × 5 | 72 | Not analyzed | Lung | 19 |
1 × 8b | 24 | Not analyzed | No data | 17 |
2 × 2b | 24, 48, 72 | Not analyzed | No data | 15 |
2 × 2.25b | 24, 48 | 24 h: 7.15/13; 48 h: 8.03/13; total histological score (based on edema: 0–4, necrosis: 0–4, hemorrhage: 0–1, inflammatory cell infiltration: 0–4) | Lung | 16 |
2 × 0.04b | ? | No damage (just after dendritic cell depletion) | None | 21 |
1 × 0.000004b | 72 | 6/16 total histological score (based on edema: 0–4, inflammation: 0–4, acinar necrosis: 0–4, hemorrhage and fat necrosis: 0–4) | Lung | 20 |
