Figure 3
Prostates dissected from PBCre4/Foxa1loxp/loxp mice exhibit progressive hyperplasia with cribriform patterning. Anterior, dorsal, ventral, and lateral prostatic tissue dissected from 7-, 24-, and 33-week-old Foxa1loxp/loxp control mice, which exhibit normal histomorphology following H&E stain (a). Conversely, H&E stain of anterior, dorsal, ventral, and lateral prostatic tissue dissected from age-matched PBCre4/Foxa1loxp/loxp mice reveals largely progressive hyperplasia with extensive cribriform patterning (b). This phenotype was most pronounced in the anterior prostate.
