Figure 2 | Laboratory Investigation

Figure 2

From: Basal cells of the human airways acquire mesenchymal traits in idiopathic pulmonary fibrosis and in culture

Figure 2

UltroserG induces epithelial-to-mesenchymal transition in a subset of VA10 cells. Sub-population of cells cultured in UltroserG medium (UG-treated) show elongated phenotype (top panel, arrows). EpCAM and CK14 immunostaining reveals an EpCam/CK14-negative mesenchymal sub-population in treated cells (middle panel, arrows). Double staining for E- and N-cadherin also shows two distinct cellular sub-populations in treated cells indicating a cadherin switch (bottom panel, outline). Cells were counterstained with TOPRO-3 nuclear stain (middle and bottom panel). Bar 200 μm.

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