Figure 1

(a) Immunohistochemical staining for the SIRT1 protein in a normal endometrium (upper lane) and endometrial carcinoma (lower lane). (b) Positivity index (maximum score=100) in the groups classified by BMI (low: BMI<25 and high: BMI⩾25), menstrual cycle, and histology. Box plot: box describes 25–75 percentiles. Lines in boxes show the median. Lines above/under the box show the maximum/minimum. Dots by circles are scores over 1.5xIQR. *P<0.05, NS: No significant difference. (c) PIs in the clinicopathological status. *P<0.05. (d) Overall survival and disease-free survival of patients with PI<50 and PI⩾50 using the Kaplan–Meier method. BMI, body mass index; CA, carcinoma; G1-3: endometrioid adenocarcinoma grades 1–3; HP, hyperplasia; IQR, interquartile range; LNM, lymph node metastasis; LVSI, lymph-vascular space invasion; MI, myometrial invasion (−negative, +positive in under half of the myometrium, ++ positive in over half of the myometrium); N, normal; NS, no significant difference; PI, positivity index; PM, post-menopause; PP, proliferative phase; SP, secretory phase.