Figure 3
From: Wnt signaling in cartilage development and diseases: lessons from animal studies
Pathological features of OA and dysregulation of Wnt and Wnt-related molecule expression in human OA. (a) Affected articular cartilage represents matrix degradation, including loss of cartilage matrix, fissure formation, erosion, and loss of cartilage structure. Inflammatory changes in the synovium (synovitis), osteophyte formation, and thickening of subchondral bone are also observed. (b) Wnts and Wnt-related genes/proteins that are upregulated or downregulated in the articular cartilage and synovial tissues.
