Figure 6
From: Recombinant human MFG-E8 ameliorates colon damage in DSS- and TNBS-induced colitis in mice
rhMFG-E8 decreases the expression of neutrophil chemoattractants in mice with DSS- and TNBS-induced colitis. cDNA from the descending colons of mice exposed to DSS (n=5/group) or transverse colons of mice exposed to TBNS (n=10/group) was used for qPCR amplification. (a) Expression of the neutrophil chemoattractants KC and MIP-2 was increased in mice exposed to DSS and treated with vehicle, and decreased dose-dependently in mice treated with rhMFG-8. (b) KC and MIP-2 were also increased in the colons of mice exposed to TNBS and treated with vehicle, and decreased dose-dependently in mice treated with rhMFG-8. Ctrl=control; Veh=vehicle; 60=rhMFG-E8 60 μg/kg/day; 120=rhMFG-E8 120 μg/kg/day; *P<0.05 vs control; #P<0.05 vs vehicle.
