Figure 1

Effects of high-cholesterol diet (HCD) on liver steatosis in wild-type (WT) and iNOS-deficient mice (iNOS(−/−)). WT and iNOS-deficient mice were fed with control diet (CD) (n=3–4, white bars) or HCD (n=6–7, black bars) for 6 weeks. (a) iNOS protein levels. (b) Hematoxylin and eosin (H&E)-stained sections of representative liver samples. (c) Liver weight (g); (d) body weight (BW) (g); (e) liver weight (% BW); and hepatic (f) lipids and (g) cholesterol levels. Results are means±s.e.m. *P≤0.05, **P≤0.01, ***P≤0.001 vs WT fed with CD; ^##P≤0.01 vs WT fed with HCD. NS, not specific.