Figure 4 | Laboratory Investigation

Figure 4

From: Overexpression of SULT2B1b is an independent prognostic indicator and promotes cell growth and invasion in colorectal carcinoma

Figure 4Figure 4

SULT2B1b silencing inhibits the proliferation, motility, and invasion of CRC cells. (a) DLD1 or HCT15 cells were infected with lentiviral-delivering scrambled control siRNA (LV-siSCR) or SULT2B1b siRNA (LV-siSULT2B1b) and protein levels of SULT2B1b were evaluated by western blot assay. (b) Cell viability of DLD1 or HCT15 cells infected with LV-siSCR or LV-siSULT2B1b was determined by the Cell Counting Kit 8 assay. Plots are represented as mean±s.e.m. of data from three independent experiments. *P<0.05. (c–e) Effects of SULT2B1b depletion on the proliferation, migration, and invasion of DLD1 or HCT15 cells were assessed by the colony-forming assay (c), transwell migration assay (d), and matrigel invasion assay (e), respectively. Representative results are shown in the left panel. Plots in the right panel are represented as mean±s.e.m. of data from three independent experiments. *P<0.05.

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