Table 3 Univariate and multivariate analyses of SULT2B1b expression and patients’ survival in the Luoyang cohort (n=202)

From: Overexpression of SULT2B1b is an independent prognostic indicator and promotes cell growth and invasion in colorectal carcinoma

  

Univariate analysis

Multivariate analysisa

Variables

Categories

HR

95% CI

P-value

HR

95% CI

P-value

Disease-specific survival

 Age (years)

≥60/<60

2.049

1.208–3.477

0.008

1.974

1.142–3.414

0.015

 Sex

Male/female

0.756

0.498–1.149

0.190

0.926

0.595–1.440

0.732

 Tumor location

Colon/rectum

1.003

0.760–1.322

0.985

0.915

0.683–1.227

0.554

 Tumor size (cm)

≥5/<5

1.076

0.703–1.647

0.736

1.127

0.731–1.740

0.588

 Differentiation grade

Poor/well+moderate

1.419

0.907–2.220

0.126

1.245

0.789–1.964

0.347

 TNM stage

III/I+II

2.895

1.895–4.422

<0.001

2.705

1.729–4.231

<0.001

 SULT2B1b expressionb

High/low

3.162

1.936–5.164

<0.001

2.694

1.631–4.451

<0.001

Disease-free survival

 Age ( years)

≥60/<60

1.373

0.899–2.095

0.142

1.408

0.904–2.194

0.131

 Sex

Male/female

0.783

0.539–1.138

0.200

1.025

0.691–1.519

0.904

 Tumor location

Colon/rectum

0.875

0.680–1.124

0.295

0.883

0.675–1.157

0.368

 Tumor size (cm)

≥5/<5

0.948

0.651–1.380

0.779

0.984

0.670–1.444

0.932

 Differentiation grade

Poor/well+moderate

1.380

0.922–2.065

0.118

1.172

0.778–1.765

0.448

 TNM stage

III/I+II

4.555

3.071–6.757

<0.001

4.202

2.786–6.338

<0.001

 SULT2B1b expressionb

High/low

2.278

1.525–3.403

<0.001

1.938

1.277–2.941

0.002

  1. HR, hazard ratio; SULT2B1b, sulfotransferase 2B1b; 95% CI, 95% confidence interval.
  2. Bold type indicates statistical significance.
  3. aMultivariate models were adjusted for age, sex, tumor location, tumor size, differentiation grade, and TNM stage.
  4. bFor SULT2B1b, median values were used as the cut-off point for definition of subgroups (low expression and high expression groups).
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