Table 4 Univariate and multivariate analyses of SULT2B1b expression and patients’ survival in the Shanghai cohort (n=283)

From: Overexpression of SULT2B1b is an independent prognostic indicator and promotes cell growth and invasion in colorectal carcinoma

  

Univariate analysis

Multivariate analysisa

Variables

Categories

HR

95% CI

P-value

HR

95% CI

P-value

Disease-specific survival

 Age (years)

≥60/<60

1.358

0.866–2.130

0.182

1.325

0.836–2.101

0.232

 Sex

Male/female

1.189

0.821–1.721

0.359

1.332

0.914–1.942

0.135

 Tumor location

Colon/rectum

1.100

0.886–1.365

0.388

1.004

0.803–1.255

0.972

 Tumor size (cm)

≥5/<5

1.145

0.791–1.657

0.472

1.283

0.878–1.876

0.198

 Differentiation grade

Poor/well+moderate

1.468

0.942–2.286

0.090

1.217

0.761–1.946

0.413

 TNM stage

III/I+II

2.004

1.389–2.890

<0.001

1.803

1.217–2.670

0.003

 SULT2B1b expressionb

High/low

2.945

2.030–4.273

<0.001

2.911

1.943–4.362

<0.001

Disease-free survival

 Age (years)

≥60/<60

1.042

0.710–1.529

0.833

1.048

0.707–1.555

0.815

 Sex

Male/female

1.024

0.734–1.430

0.888

1.134

0.807–1.594

0.468

 Tumor location

Colon/rectum

1.132

0.932–1.376

0.211

0.964

0.787–1.181

0.723

 Tumor size (cm)

≥5/<5

1.041

0.745–1.455

0.813

1.125

0.795–1.593

0.505

 Differentiation grade

Poor/well+moderate

1.794

1.218–2.643

0.003

1.353

0.899–2.035

0.147

 TNM stage

III/I+II

3.151

2.238–4.435

<0.001

2.829

1.968–4.067

<0.001

 SULT2B1b expressionb

High/low

2.475

1.747–3.504

<0.001

2.320

1.615–3.331

<0.001

  1. HR, hazard ratio; SULT2B1b, sulfotransferase 2B1b; 95% CI, 95% confidence interval.
  2. Bold type indicates statistical significance.
  3. aMultivariate models were adjusted for age, sex, tumor location, tumor size, differentiation grade, and TNM stage.
  4. For SULT2B1b, median values were used as the cut-off point for definition of subgroups (low expression and high expression groups).
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