Table 5 Multivariate analyses of SULT2B1b expression and survival for stage II patients in the Luoyang and Shanghai cohort

From: Overexpression of SULT2B1b is an independent prognostic indicator and promotes cell growth and invasion in colorectal carcinoma

  

Luoyang cohort

Shanghai cohort

Variables

Categories

HR

95% CI

P-value

HR

95% CI

P-value

Disease-specific survival

 Age (years)

≥60/<60

1.765

0.663–4.695

0.255

1.359

0.598–3.090

0.464

 Sex

Male/female

1.505

0.669–3.386

0.323

1.061

0.594–1.893

0.842

 Tumor location

Colon/rectum

0.994

0.632–1.563

0.980

1.321

0.924–1.889

0.127

 Tumor size (cm)

≥5/<5

0.630

0.321–1.233

0.177

0.977

0.538–1.773

0.939

 Differentiation grade

Poor/well+moderate

0.700

0.280–1.750

0.446

0.846

0.288–2.483

0.760

 SULT2B1b expressiona

High/low

6.926

2.432–19.727

<0.001

3.412

1.817–6.407

<0.001

Disease–free survival

 Age (years)

≥60/<60

1.686

0.682–4.173

0.258

1.372

0.604–3.117

0.451

 Sex

Male/female

1.440

0.663–3.128

0.357

1.085

0.607–1.939

0.783

 Tumor location

Colon/rectum

0.940

0.604–1.463

0.784

1.338

0.936–1.913

0.110

 Tumor size (cm)

≥5/<5

0.588

0.310–1.118

0.105

0.994

0.548–1.805

0.985

 Differentiation grade

Poor/well+moderate

0.622

0.253–1.527

0.300

0.850

0.289–2.496

0.767

 SULT2B1b expressiona

High/low

4.220

1.840–9.679

0.001

3.345

1.781–6.282

<0.001

  1. HR, hazard ratio; SULT2B1b, sulfotransferase 2B1b; 95% CI, 95% confidence interval.
  2. Multivariate models were adjusted for age, sex, tumor location, tumor size, and differentiation grade.
  3. Bold type indicates statistical significance.
  4. aFor SULT2B1b, median values were used as the cut-off point for definition of subgroups (low expression and high expression groups).
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