Table 1 ALT and GGT levels and HAIs of all experimental groups at different time points after the induction of liver fibrosisa

From: Automated evaluation of liver fibrosis in thioacetamide, carbon tetrachloride, and bile duct ligation rodent models using second-harmonic generation/two-photon excited fluorescence microscopy

Weekb

TAA rats

TAA mice

CCl4 mice

BDL rats

 

ALT

GGT

HAI

ALT

GGT

HAI

ALT

GGT

HAI

ALT

GGT

HAI

0

44.1±11.1

0.4±0.4

0±0

33.3±9.6

0.6±0.5

0±0

32.0±9.8

1.5±1.4

0±0

52.6±8.8

0.4±0.3

0±0

1

48.8±16.0

2.1±1.9

2±2

199.7±105.7c

0.8±0.7

7±5

144.6±52.0c

0.8±0.5

6±2

140.6±87c

47.9±25.4d

4±2

2

56.9±13.3

4.7±4.1

8±3

179.9±83.7c

0.5±0.5

7±5

118.6±28.3c

0.6±0.3

6±6

157.3±55.1c

41.8±20.5d

6±2

3

56.9±19.4

8.0±5.7

8±3

164.9±62c

1.7±1.7

7±4

103.0±39.7c

0.4±0.4

9±3

151.8±41.6c

60.2±19.7d

8±2

4

55.1±16.8

7.4±7.2

9±4

129.2±26.3c

0.5±0.4

8±5

180.0±28.1c

0.6±0.4

11±1

164.2±55.2c

62.4±29.6d

8±1

5

NA

NA

NA

NA

NA

NA

NA

NA

NA

153.9±43.6c

66.0±35.0d

9±2

  1. Abbreviations: ALT, alanine aminotransferase; BDL, bile duct ligation; CCl4, carbon tetrachloride; GGT, γ-glutamyl transpeptidase; HAI, histological activity index; NA, not applicable; TAA, thioacetamide.
  2. aThe values are expressed as means plus/minus s.e.
  3. bFor the TAA rat, TAA mouse, and CCl4 mouse models, 0, 1, 2, 3, and 4 correspond to weeks 0, 4, 8, 12, and 16, respectively, whereas for the BDL rat model, 0, 1, 2, 3, 4, and 5 correspond to weeks 0, 1, 2, 3, 4, and 5, respectively.
  4. cP<0.05 vs week 0.
  5. dP<0.05 vs week 0.
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