Table 3 AUC values of CPA and HYP content and the shared parameters in each Ishak fibrosis stage in the four fibrosis models

From: Automated evaluation of liver fibrosis in thioacetamide, carbon tetrachloride, and bile duct ligation rodent models using second-harmonic generation/two-photon excited fluorescence microscopy

Fibrosis stage

TAA rats

TAA mice

CCl4 mice

BDL rats

 

CPA

HYP

Shared parameters

CPA

HYP

Shared parameters

CPA

HYP

Shared parameters

CPA

HYP

Shared parameters

0 vs 1, 2, 3, 4, 5, 6

0.752

0.869

0.758

0.682

0.339

0.853

0.904

0.769

0.904

0.966

0.92

0.989

0, 1 vs 2, 3, 4, 5, 6

0.875

0.809

0.892

0.674

0.522

0.833

0.888

0.159

0.954

0.832

0.934

0.936

0, 1, 2 vs 3, 4, 5, 6

0.827

0.817

0.895

0.847

0.893

0.942

0.893

0.914

0.899

0.888

0.908

0.901

0, 1, 2, 3 vs 4, 5, 6

0.885

0.795

0.922

0.874

0.892

0.945

0.832

0.887

0.784

0.958

0.969

0.972

0, 1, 2, 3, 4 vs 5, 6

0.842

0.719

0.89

0.793

0.806

0.876

0.753

0.898

0.713

0.678

0.902

0.874

0, 1, 2, 3, 4, 5 vs 6

0.908

0.804

0.916

0.606

0.802

0.808

0.865

0.765

0.863

   
  1. Abbreviations: AUC, area under ROC curve; BDL, bile duct ligation; CCl4, carbon tetrachloride; CPA, collagen proportionate area; HYP, hydroxyproline; TAA, thioacetamide.