Figure 2
From: Apolipoprotein A-1 regulates osteoblast and lipoblast precursor cells in mice
Bone quality and fat content in apoA-1−/− and WT mice. (a) Collagen cross-linking, by Raman Spectroscopy, revealed a substantial decrease (29%) for the knock out compared with the WT mice. Statistical significance was considered at P=0.04, n=5. (b) Analysis of biomechanical properties of mice femora, using 3-point bending, showed that max load to fracture (A), bending resistance (B), and elasticity (C) were decreased in bone obtained from apoA-1−/− mice compared with WT bone. Only reduction in elasticity was significant P=0.02 due to variability, although trend in elasticity was seen (P=0.10). (c) Histological and histomorphometric analysis revealed that the bone marrow of the apoA-1-deficient mice had significantly elevated adipocyte area in comparison with the WT group; the difference is highly significant in quantitative analysis of four femora (n=4, P=0.004).
