Figure 10 | Laboratory Investigation

Figure 10

From: Perilipin 5 restores the formation of lipid droplets in activated hepatic stellate cells and inhibits their activation

Figure 10

A simplified action model for Plin5 to inhibit the activation of HSC. Expression of Plin5 is depleted in HSC on activation. Introduction of exogenous Plin5 in HSC by transduction of LV-Plin5-YFP (LV-Plin5) restores the formation of cellular LDs in HSC and stimulates the activation of AMPK, which, in turn, induces the expression of endogenous Plin5. The activation of AMP results in the elevation of cellular lipid content in HSC by inducing lipogenesis and suppressing lipolysis. On the other hand, the activation of AMPK stimulates the transcription activity of Nrf2 and the expression of GCL subunits, leading to the elevation of cellular levels of GSH and the attenuation of cellular oxidative stress in HSC. These effects collectively inhibit HSC activation.

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