Figure 5
From: Downregulation of c-Myc is involved in TLR3-mediated tumor death of neuroblastoma xenografts
Activation of caspase 3 and cleavage of PARP-1 shown as evidence of apoptosis induced by poly(I:C) treatment in SK-N-AS xenografts. (a) Representative images of immunohistochemical staining for active caspase 3 and cleaved PARP-1 performed on tissue sections from SK-N-AS xenografts with or without poly(I:C) treatment. (b and c) Quantitative analyses of active caspase 3 and cleaved PARP-1 by immunoreactivity scores. Data represent mean immunoreactivity score±s.e.m. for each group. Original magnification, × 400. Scale bar, 25 μm. *P<0.05, ***P<0.001.
