Figure 6
From: Downregulation of c-Myc is involved in TLR3-mediated tumor death of neuroblastoma xenografts
Illustration for the relationship among TLR3-agonist poly(I:C), c-Myc, NF-κB, and ROS in innate immune responses. Poly(I:C) treatment may trigger TLR3 signaling to initiate innate immunity followed by activation of IRF3 and type I IFNs. Subsequently, c-Myc is downregulated by poly(I:C), resulting in activation of NF-κB, followed by overexpression of MnSOD, a NF-κB transcriptional target gene, to facilitate ROS generation. TLR3 signaling also activates caspase 3 to cleave PARP-1 to impair DNA repair. Finally, apoptosis and growth arrest are induced by TLR3-mediated innate immune responses in MYCN-non-amplified NB xenografts.
