Figure 4 | Laboratory Investigation

Figure 4

From: Hedgehog signaling pathway affects the sensitivity of hepatoma cells to drug therapy through the ABCC1 transporter

Figure 4

Cell viability of various subpopulations in exposure to chemotherapeutic agents. CD133+/EpCAM+, CD133−/EpCAM−, Huh-7-DN, and Huh-7-trans subpopulations were treated with chemotherapeutic drugs as indicated concentration for 24 h. Cell viability was determined by MTT and expressed as percentage. CD133+/EpCAM+, CD133−/EpCAM−, Huh-7-DN, and Huh-7-trans subpopulations were treated with itraconazole (0–10 μM) only (a and b); or with LDE225 (0–10 μM) plus/minus sorafenib at 10 μM (c–f). *P<0.05, **P<0.01 compared with LDE225 only at corresponding concentrations.

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