Figure 5 | Laboratory Investigation

Figure 5

From: Hedgehog signaling pathway affects the sensitivity of hepatoma cells to drug therapy through the ABCC1 transporter

Figure 5

Expression of Hh signaling pathway and multidrug-resistant ABC transporters in various subpopulations. Expression of Hh signaling transcription factors, Gli-1 and Gli-2; ABC transporters ABCC1, ABCB1, ABCG2 was determined in Huh-7, CD133+/EpCAM+, CD133−/EpCAM−, Huh-7-DN, and Huh-7-trans subpopulations by quantitative RT-PCR using Huh-7 as a control. (a and b) Relative Gli-1 and Gli-2 mRNA expression over primary human hepatocyte (PH). (c) Relative BCL-2 mRNA expression levels (fold) over Huh-7 cells. (d–f) Relative ABCC1, ABCB1, and ABCG2 mRNA expression levels (fold) over primary human hepatocyte (PH). *P<0.05 compared with Huh-7.

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