Figure 6
Roles of Musashi and Numb in regulation of asymmetric and symmetric cell division in BC CML. Chimeric upstream transcription factors such as NUP98-HOXA9 can induce the Musashi RNA binding factor that is important in determining cell fate. Musashi is elevated in BC CML; in contrast, the Numb protein is detected at low levels in BC CML. The Numb protein plays a key role in asymmetric cell division and it is usually present in one daughter cell after division and not the other, allowing different cellular fates. Numb can regulate many pathways important in BC CML including Hh, Notch and p53 that can also be regulated by GSK-3. This figure is presented to provide the reader an idea of the importance of regulation of asymmetric vs symmetric division in BC CML and how division can be regulated by Numb and upstream Musashi and NUP98-HOXA9.
