Table 1 Influence of covariates on the likelihood of having a day 14 marrow and of achieving CR
From: Value of routine ‘day 14’ marrow exam in newly diagnosed AML
Parameter (no. of patients) | Patients (pts.) with a day 14 marrow (%) | Multivariate odds ratio for having day 14 marrow (P-value) | Patients achieving CR | Multivariate odds ratio for achieving CR (P-value) |
|---|---|---|---|---|
All patients (154) | ||||
Older age (numerical) | — | 0.98 (0.30) | — | 1.00 (0.92) |
Higher pre-treatment blast% (numerical) | — | 1.01 (0.11) | — | 0.99 (0.40) |
Type | ||||
De novo (102 pts.) | 76 (75%) | 1.00 | 77 (75%) | 1.00 |
Secondary (52 pts.) | 40 (77%) | 1.12 (0.80) | 33 (63%) | 0.60 (0.20) |
Cytogenetic risk | ||||
Favorable (30 pts.) | 18 (60%) | 1.00 | 28 (93% | 1.00 |
Intermediate/poor (124 pts.) | 98 (79%) | 2.78 (0.03) | 82 (66%) | 0.14 (0.01) |
Treatment | ||||
HiDAC (40 pts.) | 26 (65%) | 1.00 | 26 (65%) | 1.00 |
7+3 (114 pts.) | 90 (79%) | 2.22 (0.06) | 84 (74%) | 1.57 (0.28) |
Day 14 marrow examined | ||||
Yes (116 pts.) | — | — | 83 (72%) | 1.00 |
No (38 pts.) | 27 (71%) | 0.77 (0.56) | ||
7+3 patients (114) | ||||
Older age | — | 0.98 (0.20) | — | 1.01 (0.56) |
Higher pre-treatment blast% | 1.02 (0.02) | — | 0.99 (0.34) | |
Type | ||||
De novo (74 pts.) | 60 (81%) | 1.00 | 58 (78%) | 1.00 |
Secondary (40 pts.) | 30 (75%) | 0.91 (0.86) | 26 (65%) | 0.53 (0.19) |
Risk | ||||
Favorable (22 pts.) | 17 (77%) | 1.00 | 21 (95%) | 1.00 |
Intermediate/poor (92) | 73 (79%) | 1.37 (0.61) | 63 (68%) | 0.10 (0.04) |
Day 14 marrow examined | ||||
Yes (90 pts.) | — | — | 67 (74%) | 1.00 |
No (24 pts.) | 17 (71%) | 0.77 (0.64) | ||
HiDAC patients (40) | ||||
Older age | — | 1.02 (0.54) | — | 0.98 (0.46) |
Higher pre-treatment blast% | — | 0.99 (0.45) | — | 1.00 (0.91) |
Type | ||||
De novo (28 pts.) | 16 (57%) | 1.00 | 19 (68%) | 1.00 |
Secondary (12 pts.) | 10 (83%) | 2.50 (0.38) | 7 (58%) | 0.77 (0.72) |
Risk | ||||
Favorable ( 8 pts.) | 1 (13%) | 1.00 | 7 (88%) | 1.00 |
Intermediate/poor (32 pts.) | 25 (78%) | 25.0 (0.007) | 19 (59%) | 0.18 (0.18) |
Day 14 marrow examined | ||||
Yes (26 pts.) | — | — | 16 (62%) | 1.00 |
No (14 pts.) | 10 (71%) | 0.77 (0.76) | ||
