Table 3 Outcome at 5 years according to PTEN/RAS genotype in the NOTCH1/FBXW7 subgroups

NOTCH1/FBXW7 subgroup	PTEN/RAS genotype	RFS			OS
		Events/n	% (95% CI)	P^a	Events/n	% (95% CI)	P^a
NOTCH1±FBXW7^Double	PTEN ^WT	2/32	94% (77–98%)	0.57	0/32	100%	N/A^b
	PTEN ^ABN	0/5	100%		0/5	100%
	PTEN/RAS ^WT	2/28	93% (74–98%)	0.42	0/28	100%	N/A^b
	PTEN/RAS ^ABN	0/9	100%		0/9	100%
NOTCH1 ^Single FBXW7 ^WT	PTEN ^WT	7/41	83% (67–93%)	0.68	4/41	90% (76–96%)	0.24
	PTEN ^ABN	3/14	79% (47–93%)		3/14	79% (47–93%)
	PTEN/RAS ^WT	7/38	81% (64–91%)	0.98	4/38	89% (74–96%)	0.44
	PTEN/RAS ^ABN	3/17	82% (55–94%)		3/17	82% (55–94%)
NOTCH1 ^WT FBXW7 ^WT	PTEN ^WT	5/36	85% (68–94%)	0.82	6/36	83% (67–92%)	0.60
	PTEN ^ABN	3/13	83% (48–96%)		3/13	77% (47–93%)
	PTEN/RAS ^WT	5/33	87% (69–95%)	0.49	5/33	85% (67–93%)	0.39
	PTEN/RAS ^ABN	4/16	80% (50–93%)		4/16	75% (46–90%)

Abbreviations: ABN, abnormal; CI, confidence interval; OS, overall survival; RFS, relapse-free survival; WT, wild type.
^aP-values: Log-rank test.
^bNot applicable as no deaths reported.

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