Figure 5
The 2D in vitro modeling of MDS. (a) Fold expansion of cells observed after LTC of patient CD34+ cells grown on MSCs and/or MS5 for a period of 4 weeks (patients n=9; NA, not available). (b) Total number of colonies (per 1 × 105 CD45+ seeded cells) generated following the LTC (obtained from (a)) for patients across various MDS WHO subtypes (patients n=9). (c) Comparison of burst forming unit- erythroid/granulocyte-macrophage colony ratio from primary CD34+ cells versus post-LTC (patients n=3; NA, not available).
