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Prevention and management of adverse events of Novel agents in multiple myeloma: A consensus of the european myeloma network
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  • Review Article
  • Open access
  • Published: 18 December 2017

Review Article

Prevention and management of adverse events of Novel agents in multiple myeloma: A consensus of the european myeloma network

  • H Ludwig1,
  • M Delforge2,
  • T Facon3,
  • H Einsele4,
  • F Gay5,
  • P Moreau6,
  • H Avet-Loiseau7,
  • M Boccadoro8,
  • R Hajek9,
  • M Mohty10,
  • M Cavo11,
  • M A Dimopoulos12,
  • J F San-Miguel13,
  • E Terpos12,
  • S Zweegman14,
  • L Garderet10,
  • M-V Mateos15,
  • G Cook16,
  • X Leleu17,
  • H Goldschmidt18,
  • G Jackson19,
  • M Kaiser20,
  • K Weisel21,
  • N W C J van de Donk14,
  • A Waage22,
  • M Beksac23,
  • U H Mellqvist24,
  • M Engelhardt25,
  • J Caers26,
  • C Driessen27 &
  • …
  • P Sonneveld28 

Leukemia (2017)Cite this article

  • 8948 Accesses

  • 16 Citations

  • 9 Altmetric

  • Metrics details

Subjects

  • Adverse effects
  • Drug safety
  • Myeloma

Abstract

During the last few years, several new drugs have been introduced for treatment of patients with multiple myeloma, which have significantly improved treatment outcome. All of these novel substances differ at least in part in their mode of action from similar drugs of the same drug class, or are representatives of new drugs classes, and as such present with very specific side effect profiles. In this review, we summarize these adverse events, provide information on their prevention, and give practical guidance for monitoring of patients and for management of adverse events.

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Author information

Authors and Affiliations

  1. Wilhelminen Cancer Research Institute, Vienna, Austria

    H Ludwig

  2. Department of Development and Regeneration, Stem Cell Biology and Embryology Unit, Catholic University Leuven, Leuven, Belgium

    M Delforge

  3. Department of Hematology, Lille University Hospital, Lille, France

    T Facon

  4. Department of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany

    H Einsele

  5. Division of Hematology, Myeloma Unit, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, University of Torino, Torino, Italy

    F Gay

  6. Department of Hematology, University Hospital, University of Nantes, Nantes, France

    P Moreau

  7. Centre de Recherches en Cancerologie de Toulouse CRCT, Institut National de la Sante et de la Recherche Medicale, Université Toulouse, Toulouse, France

    H Avet-Loiseau

  8. Division of Hematology, Citta della Salute e della Scienza, University of Torino, Torino, Italy

    M Boccadoro

  9. Faculty of Medicine, University Hospital Ostrava, University of Ostrava, Ostrava, Czech Republic

    R Hajek

  10. Department of Haematology, Saint Antoine Hospital, University Pierre and Marie Curie, and INSERM UMRs 938, Paris, France

    M Mohty & L Garderet

  11. a 'Seràgnoli' Institute of Hematology, Bologna University School of Medicine, Bologna, Italy

    M Cavo

  12. Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece

    M A Dimopoulos & E Terpos

  13. Department of Hematology, Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada (CIMA), IDISNA, CIBERONC, Pamplona, Spain

    J F San-Miguel

  14. Department of Hematology, VU University Medical Center, Amsterdam, Netherlands

    S Zweegman & N W C J van de Donk

  15. Hospital Universitario de Salamanca, Instituto Biosanitario de Salamanca (IBSAL), Salamanca, Spain

    M-V Mateos

  16. Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK

    G Cook

  17. Service d'Hématologie et Thérapie Cellulaire, PRC, and Inserm CIC1402, Hospital de la Miléterie, Poitiers, France

    X Leleu

  18. National Center for Tumor Diseases, Heidelberg Medical University, Heidelberg, Germany

    H Goldschmidt

  19. Department of Hematology, Newcastle University, Newcastle, UK

    G Jackson

  20. Myeloma Group, The Institute of Cancer Research ICR, London, UK

    M Kaiser

  21. Department of Hematology and Oncology, University of Tuebingen, Tuebingen, Germany

    K Weisel

  22. Department of Hematology, St Olavs Hospital, and IKOM, NTNU, Trondheim, Norway

    A Waage

  23. Department of Medicine, Ankara University, Ankara, Turkey

    M Beksac

  24. Department of Hematology Sahlgrenska Hospital, Gothenburg, Sweden

    U H Mellqvist

  25. Department of Hematology and Oncology, University of Freiburg Medical Center, Freiburg, Germany

    M Engelhardt

  26. Department of Hematology, University Hospital of Liège, Liège, Belgium

    J Caers

  27. Department of Oncology and Hematology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland

    C Driessen

  28. Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, Netherlands

    P Sonneveld

Authors
  1. H Ludwig
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  2. M Delforge
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  3. T Facon
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  4. H Einsele
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  5. F Gay
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  6. P Moreau
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  7. H Avet-Loiseau
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  8. M Boccadoro
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  9. R Hajek
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  10. M Mohty
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  11. M Cavo
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  12. M A Dimopoulos
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  13. J F San-Miguel
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  14. E Terpos
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  15. S Zweegman
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  16. L Garderet
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  17. M-V Mateos
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  18. G Cook
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  19. X Leleu
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  20. H Goldschmidt
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  21. G Jackson
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  22. M Kaiser
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  23. K Weisel
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  24. N W C J van de Donk
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  25. A Waage
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  26. M Beksac
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  27. U H Mellqvist
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  28. M Engelhardt
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  29. J Caers
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  30. C Driessen
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  31. P Sonneveld
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Corresponding author

Correspondence to H Ludwig.

Additional information

This manuscript has been endorsed by the European Haematology Association (EHA)

Rights and permissions

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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Cite this article

Ludwig, H., Delforge, M., Facon, T. et al. Prevention and management of adverse events of Novel agents in multiple myeloma: A consensus of the european myeloma network. Leukemia (2017). https://doi.org/10.1038/leu.2017.353

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  • Received: 10 October 2017

  • Revised: 23 November 2017

  • Accepted: 30 November 2017

  • Published: 18 December 2017

  • DOI: https://doi.org/10.1038/leu.2017.353

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This article is cited by

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    • Alessandra Larocca
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    Leukemia (2018)

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