Figure 1
From: Resistance to HSV-1 infection in the epithelium resides with the novel innate sensor, IFI-16
The loss of TLR signaling has not affect on viral containment in the cornea. WT, Trif−/−, MyD88−/−, DKO, and CD118−/− mice were infected with 1,000 p.f.u. HSV-1 per eye. At the indicated time pi, mice were killed and corneas harvested. Viral levels in the cornea were then determined by plaque assay at (a) 120 (b), 24, and (c), 48 h pi. Bars represent 2–4 experiments of 2–4 corneas per group per experiment and are expressed as the mean log p.f.u. per cornea±s.e.m. **P<0.01; *P<0.05 when comparing all groups. DKO, double knockout; HSV, herpes simplex virus; pi, post infection; TLR, Toll-like receptor; WT, wild type.
