Figure 2
From: The role of neutrophils during intestinal inflammation
The various steps of transepithelial migration (basolateral adhesion, transmigration, and apical adhesion) and pathological consequences of massive polymorphonuclear leukocytes (PMN) migration across intestinal epithelium (blue text). Epithelial proteins important in PMN transepithelial migration are highlighted in grey text whereas key neutrophil proteins are in red text. The photomicrograph on the top half of the figure shows a crypt abscess (red arrow) from a patient with ulcerative colitis (kindly provided by Kevin Fisher MD, PhD). The crypt epithelium (E) is being infiltrated by transmigrating PMN (yellow arrows). Water accumulation within crypts (green arrow) is the result of stimulated electrogenic chloride secretion. AJ, adherens junctions (contain E-cadherin); AMP, adenosine monophosphate; CAR, Coxsackie and adenovirus receptor; DE, desmosomes; ICAM, intercellular adhesion molecule; JAML, junctional adhesion molecule (JAM)-like molecule; MMP, matrix metalloprotease; SIRP, signal-regulatory protein; TJ, tight junctions (contain CAR). (Adapted from Chin and Parkos54).
