Figure 6
Early responses and cardiac allograft survival. Histological appearance (original magnification, ×100) of (a) B6 hearts transplanted into immunosuppressed (MR1 250 μg intraperitoneally (i.p.) day 0, CTLA4-Ig 200 μg i.p. day 2) CBA host (killed at 30 days, at which point heart was beating strongly) (n=4) and (b) B6 cardiac grafts, initially transplanted into immunosuppressed CBA mouse for 72 h and then retransplanted into untreated CBA host (shown at day 11 at the time of cessation of heart beat) (n=4). (c) Graft survival curves for groups shown in panels a and b, P<0.01. No statistically significant differences were observed between retransplants depicted here and B6→CBA cardiac transplants shown in Figure 4 (P=0.28).
