Figure 2
Intestinal inflammation is associated with nuclear translocation of CK2α. (a) CK2α expression and subcellular localization in chronically inflamed mouse colon were determined by immunohistochemistry. Magnified insets show crypts immediately adjacent to (1) and somewhat removed from (2) a mucosal ulcer. (b) Analysis of CK2α nuclear/cytoplasmic ratio in the intestinal epithelial cells (IECs) of mice with chronic dextran sulfate sodium (DSS) colitis. Results are pooled from six ulcer margins in three mice. The trendline indicates an exponential decrease with increasing distance from the ulcer.
