Figure 3
Treatment-induced remission in colitic mice alters intestinal gene expression profiles. Heat-map representing colonic gene expression profiles of pro- and anti-inflammatory mediators, chemokines, intestinal epithelial cell (IEC)-related response genes, and others in Rag−/− H+ mice with active intestinal inflammation or mice treated with anti-CD4 antibodies at days 1, 3, and 11 postdepletion (p.d) to induce remission in colitis. RNA values were normalized to the endogenous control genes Gapdh and β2-microglobulin and presented as fold induction/reduction over mice that were transferred with CD4+ CD45RBlo CD25+ T cell and subsequently depleted of CD4 T cells on day 11 p.t. Pooled data from four independent experiments with n=5–8 mice per group are shown.
