Figure 2
Perforin upregulation in blood and rectal mucosal CD8+ T-cells following T-cell receptor (TCR) stimulation. (a) Representative flow cytometry plot of the de novo perforin response in degranulating (CD107a+) CD8+ T-cells from blood and rectal mucosa. (b) Difference in perforin response to Gag, Nef, and Staphylococcal enterotoxin B (SEB) between blood and rectal degranulating (CD107a+) CD8+ T-cells in HIV+ participants (Gag, Nef), and in HIV+ and seronegative participants combined (SEB). (c) Perforin response to Gag, Nef, and SEB in degranulating (CD107a+) rectal CD8+ T-cells across HIV-disease status. Bar heights indicate mean values for each participant group. Wide horizontal bars represent medians; narrow whiskers indicate interquartile ranges; asterisks indicate level of significance as follows: * P<0.05, **P<0.01, *** P<0.001, **** P<0.0001.
