Figure 3
Reduced expression of perforin and GrzB in rectal mucosal CD8+ T-cell memory/effector populations compared with blood. (a) Representative flow cytometry plot displaying surface staining for the memory differentiation markers CD45RO, CD27, and CCR7 in blood and rectal CD8+ T-cells. (b) Frequency of memory/effector subsets within blood and rectal CD8+ T-cell populations in a consolidated group of HIV+ and seronegative participants. (c) Distribution of perforin and GrzB expression in blood and rectal CD8+ T-cell memory/effector subsets. Wide horizontal bars represent medians; narrow whiskers indicate interquartile ranges; asterisks indicate level of significance as follows: **P<0.01.
