Figure 7
From: Norovirus antagonism of B-cell antigen presentation results in impaired control of acute infection
The B-cell-dependent control of acute MNV-1 infection occurs independent of the intestinal microbiota. Groups of B6 (gray bars) and μMT (white bars) mice were orally administered PBS or a cocktail of Abx, as described in the Methods and indicated on the x axis. Both groups were then infected p.o. with 107 TCID50 units MNV-1. At 3 d.p.i., the indicated tissues were dissected and viral titers were determined by plaque assay. The data are reported as pfu per gram of tissue and the data for all mice per group (n=8–11 mice over four experiments) are averaged. Dashed lines indicate the limit of detection for each tissue. Statistical comparisons were made between B6 mice and μMT for each condition. Abx, antibiotics; d.p.i., days post infection; PBS, phosphate-buffered saline; p.o., perorally.
