Figure 3
CD4+ and CD8+ T-cell activation in the blood and gastrointestinal-associated lymphoid tissue (GALT) and associations with invariant natural killer T (iNKT) cell cytokine production. Coexpression of CD38 and HLA-DR on (a) CD4+ T cells and (b) CD8+ T cells in the blood and GALT of controls (n=7) and HIV-infected subjects (n=18). Associations between interleukin-10-positive (IL-10+) iNKT cells in the (c) blood and CD38+HLA-DR+ CD4+ and (d) CD8+ T cells of HIV-infected subjects. Associations between IL-10+ and IL-4+ iNKT cells in the GALT of (e) HIV-infected subjects and CD38+HLA-DR+ CD4+ and (f) CD8+ T cells, respectively. *P<0.05 and **P<0.01. PBMC, peripheral blood mononuclear cell.
