Figure 4
Markers of microbial translocation and associations with invariant natural killer T (iNKT) cell cytokine production. The levels of (a) sCD14, (b) LPS-binding protein (LBP), (c) intestinal fatty acid-binding protein 2 (I-FABP2), and (d) kynurenine/tryptophan (Kyn/Trp) ratio were determined in the serum of healthy controls (n=9) and HIV-infected subjects (n=23). Associations between the levels of sCD14 in HIV-infected subjects and IL4+ iNKT cells in the (e) blood and IL10+ iNKT cells in the (f) gastrointestinal-associated lymphoid tissue (GALT). Associations between LBP levels in the serum of HIV-infected subjects and (g) IL4+ and (h) TNF+ iNKT cells in the GALT. (i) Association between Kyn/Trp ratio in HIV-infected subjects and IL4+ iNKT cells in the blood. *P<0.05, **P<0.01 and ***P<0.001. PBMC, peripheral blood mononuclear cell.
