Table 2 Correlation between EphA1 protein expression and clinicopathologic parameters in 111 colorectal carcinomas
From: Downregulation of EphA1 in colorectal carcinomas correlates with invasion and metastasis
Case number | Downregulation | No difference | Upregulation | P-value | |
|---|---|---|---|---|---|
Overall | 111 | 60 | 17 | 34 | — |
Sex | |||||
Male | 66 | 37 | 14 | 15 | 0.028 |
Female | 45 | 23 | 3 | 19 | |
Age (years) | |||||
≤55 | 49 | 31 | 8 | 10 | 0.109 |
>55 | 62 | 29 | 9 | 24 | |
Location | |||||
Rectum+sigmoid colon | 81 | 40 | 12 | 29 | 0.144 |
Colon | 30 | 20 | 5 | 5 | |
Tumor size (cm) | |||||
≤5 | 80 | 40 | 14 | 26 | 0.352 |
>5 | 31 | 20 | 3 | 8 | |
Depth of wall invasion | |||||
Mucosa+submucosa | 10 | 3 | 3 | 4 | 0.003 |
Muscularis propria | 24 | 7 | 3 | 14 | |
Subserosa+serosa | 77 | 50 | 11 | 16 | |
Tumor differentiation | |||||
Well+moderate | 80 | 37 | 15 | 28 | 0.027 |
Poor+mucinous | 31 | 23 | 2 | 6 | |
Lymphatic metastases | |||||
Negative | 66 | 29 | 12 | 25 | 0.034 |
Positive | 45 | 31 | 5 | 9 | |
Clinical stage (TNM) | |||||
I | 28 | 7 | 5 | 16 | 0.003 |
II | 37 | 22 | 7 | 8 | |
III+IV | 46 | 31 | 5 | 10 | |
Stage (Dukes) | |||||
A+B | 65 | 29 | 12 | 24 | 0.06 |
C | 46 | 31 | 5 | 10 | |
