Figure 2 | Modern Pathology

Figure 2

From: Primary cutaneous CD4-positive small/medium-sized pleomorphic T-cell lymphoma: a clonal T-cell lymphoproliferative disorder with indolent behavior

Figure 2

Immunophenotype of primary cutaneous CD4-positive small/medium-sized pleomorphic T-cell lymphoma, case 9. (a) The lymphoid infiltrate is mostly composed of CD3-positive T cells extensively infiltrating full thickness of the dermis (immunoperoxidase, original magnification × 40). (b) There is invariably a significant CD20-positive B-cell population that is arranged into ill defined nodules (immunoperoxidase, original magnification × 40). (c) High-power view of CD3 and T-cell receptor β-chain-β F1, (d) staining highlights cytological aypia in a subset of the T cells (immunoperoxidase, original magnification (c) × 400, (d) × 1000). (e–f) The lymphoid infiltrate is overwhelmingly CD4 positive (e), but appears mostly negative for CD8 (f) (immunoperoxidase, original magnification × 400).

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