Table 3 Epidermal growth factor receptor expression in adrenal tissue samples

From: Epidermal growth factor receptor in adrenocortical tumors: analysis of gene sequence, protein expression and correlation with clinical outcome

EGFR expression score

0+

1+

2+

3+

(a)

 ACC primary tumor (n=129)

53

20

18

38

 ACC local recurrence (n=18)

7

2

1

8

 ACC distant metastases (n=14)

5

6

1

2

 Normal adrenal gland (n=5)

5

0

0

0

 Aldosterone-producing ACA (n=5)

4

1

0

0

 Cortisol-producing ACA (n=5)

5

0

0

0

 Endocrine inactive ACA (n=4)

4

0

0

0

(b)

 ACC primary tumor (n=135)

33

24

30

48

 ACC local recurrence (n=19)

4

1

4

10

 ACC distant metastases (n=15)

4

6

3

2

 Normal adrenal gland (n=5)

5

0

0

0

 Aldosterone-producing ACA (n=12)

11

1

0

0

 Cortisol-producing ACA (n=10)

10

0

0

0

 Endocrine-inactive ACA (n=9)

9

0

0

0

  1. Epidermal growth factor receptor expression score: 0, no; 1+, weak; 2+, moderate; and 3+, strong membrane staining.
  2. Part (a) shows adrenal tissue samples analyzable in the tissue microarrays, and part (b) shows all adrenal tissue samples after staining the original tissue specimens in all samples that were epidermal growth factor receptor negative on the tissue microarray+additional 6 adrenocortical carcinomas and 18 adrenocortical adenoma samples.
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